منابع مشابه
A double-blind clinical trial to determine if an interaction exists between diclofenac sodium and the oral anticoagulant acenocoumarol (nicoumalone).
A double-blind crossover trial between diclofenac sodium and placebo was carried out in 32 hospitalized patients who were thought to be stabilized on concurrent anticoagulant therapy with acenocoumarol. The object of the trial was to investigate any possible interaction between diclofenac and anticoagulant by monitoring prothrombin times daily through the four week period. No statistically sign...
متن کاملDVT: A New Era in Anticoagulant Therapy DVT: A New Era in Anticoagulant Therapy
Thrombosis is the leading cause of morbidity and mortality in the Western world. Arterial thrombosis leads to myocardial infarction and stroke. Arterial clots are platelet-rich and fibrin-poor (so-called white clots). They are generated at sites of vascular injury under high shear rates and are prevented or treated with antiplatelet drugs.1 However, because of the fact that the thrombin is a po...
متن کاملClinical Evaluation of a New Oral Anticoagulant
SINCE the introduction of Dicumarol into clinical usage in 1942, the efficacy of anticoagulant therapy for the treatment of thromboembolic disorders has been well established. The search for more efficient prothrombin depressants has continued and the clinical usefulness of many such drugs has been investigated. Those that have been found acceptable thus far have all been either coumarin or ind...
متن کاملPPA-3682-dabigatran a new oral anticoagulant
Correspondence: Nadia rosencher Anaesthesiology Department, Hôpital Cochin (AP-HP), rené Descartes University, Paris 75014 France email: [email protected] Abstract: The recent development of new oral anticoagulants, of which dabigatran etexilate is currently at the most advanced stage of development, is the greatest advance in the provision of convenient anticoagulation therapy for ma...
متن کاملChlorphenindione--a new longacting oral anticoagulant.
Preliminary reports have shown that chlorphenindione is a long-acting oral anticoaguilant (Lund, 1957; Pugatsch, 1960). The chemical structure of the drug, which is one of the indanedione group, is as follows: OH Cl 0 2-(4'-chlorphenyl)-indanedione-(1,3) The aim of the present investigation was to assess the value of this new agent in the short-term treatment of thromboembolic disorders in comp...
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ژورنال
عنوان ژورنال: BMJ
سال: 1959
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.5131.1211